In recent years, translational research involving humans and animals has uncovered
biological and physiological pathways that explain associations between early adverse …

Adverse experiences during sensitive postnatal developmental periods can disrupt the
calibration of fundamental systems and increase the risk of a wide range of adult disease …

Stress, particularly when experienced early in life, can have profound implications for mental
health. Previous research covering various tissues such as the brain, suggests that the …

Early life stress in humans (ie maltreatment, violence exposure, loss of a loved one) and in
rodents (ie disrupted attachment or nesting, electric shock, restraint, predator odor) occurs …

Epidemiological and clinical studies have shown that children exposed to adverse
experiences are at increased risk for the development of depression, anxiety disorders, and …

Early life adversity is associated with long-term effects on physical and mental health later in
life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific …

The early environment, including maternal characteristics, provides many cues to young
organisms that shape their long-term physical and mental health. Identifying the earliest …

It has long been recognized that early adversity can have life‐long consequences, and the
extent to which this is true is gaining increasing attention. A growing body of literature …

Childhood adversity affects later health, but the underlying molecular mechanisms are
unclear. Although there is some evidence from animal models and case-control studies of a …

Fetal exposure to prenatal stress can have significant consequences on short-and long-term
health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible …