In vitro assembly of virus-like particles and their applications

DT Le, KM Müller - Life, 2021 - mdpi.com
Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery.
Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous …

Next generation vaccines and vectors: Designing downstream processes for recombinant protein‐based virus‐like particles

CL Effio, J Hubbuch - Biotechnology journal, 2015 - Wiley Online Library
In recent years, the development of novel recombinant virus‐like particles (VLPs) has been
generating new perspectives for the prevention of untreated and arising infectious diseases …

Development of virus‐like particles for diagnostic and prophylactic biomedical applications

B Schwarz, T Douglas - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
As ordered nanoscale architectures, viruses and virus‐like particles (VLP s) remain
unsurpassed by synthetic strategies to produce uniform and symmetric nanoparticles …

Viral vectors as vaccine platforms: from immunogenicity to impact

KJ Ewer, T Lambe, CS Rollier, AJ Spencer… - Current opinion in …, 2016 - Elsevier
Highlights•Safety and potency of simian adenovirus vectors is now well established, most
recently in infants.•Viral vectored vaccines are effective against malaria and Ebola in field …

The coming of age of virus-like particle vaccines

GT Jennings, MF Bachmann - 2008 - degruyter.com
Virus-like particles are supra-molecular assemblages, usually icosahedral or rod-like
structures. They incorporate key immunologic features of viruses which include repetitive …

[HTML][HTML] Virus like particles as a platform for cancer vaccine development

HK Ong, WS Tan, KL Ho - PeerJ, 2017 - peerj.com
Cancers have killed millions of people in human history and are still posing a serious health
problem worldwide. Therefore, there is an urgent need for developing preventive and …

Engineering virus-like particles as vaccine platforms

KM Frietze, DS Peabody, B Chackerian - Current opinion in virology, 2016 - Elsevier
Highlights•VLP have been engineered to improve their utility as vaccine platforms.•Targeted
engineering of VLPs has enhanced immunogenicity, stability, and versatility.•Predictive …

Virus like particles (VLP) as multivalent vaccine candidate against chikungunya, Japanese encephalitis, yellow fever and zika virus

H Garg, T Mehmetoglu-Gurbuz, A Joshi - Scientific Reports, 2020 - nature.com
Mosquito borne viral diseases are an emerging threat as evident from the recent outbreak of
Zika virus (ZIKV) as well as repeated outbreaks of Chikungunya (CHIKV), Yellow fever (YFV) …

New routes and opportunities for modular construction of particulate vaccines: stick, click, and glue

KD Brune, M Howarth - Frontiers in immunology, 2018 - frontiersin.org
Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-
chimeric VLP-based vaccines are highly successful licensed products (eg, hepatitis B …

Virus-like particle (VLP)-based vaccines for pandemic influenza: performance of a VLP vaccine during the 2009 influenza pandemic

C López-Macías - Human vaccines & immunotherapeutics, 2012 - Taylor & Francis
The influenza pandemic of 2009 demonstrated the inability of the established global
capacity for egg-based vaccine production technology to provide sufficient vaccine for the …