Virus-like particle vaccines: immunology and formulation for clinical translation

B Donaldson, Z Lateef, GF Walker… - Expert review of …, 2018 - Taylor & Francis
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation
from laboratory models, to routine clinical administration. While some VLP vaccines thrive …

Major findings and recent advances in virus–like particle (VLP)-based vaccines

MO Mohsen, L Zha, G Cabral-Miranda… - Seminars in …, 2017 - Elsevier
Virus-like particles (VLPs) have made giant strides in the field of vaccinology over the last
three decades. VLPs constitute versatile tools in vaccine development due to their …

[HTML][HTML] Virus-like particle vaccines and platforms for vaccine development

M Kheirvari, H Liu, E Tumban - Viruses, 2023 - mdpi.com
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use
of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human …

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Virus-like particles in vaccine development

A Roldão, MCM Mellado, LR Castilho… - Expert review of …, 2010 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

[HTML][HTML] Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

The coming of age of virus-like particle vaccines

GT Jennings, MF Bachmann - 2008 - degruyter.com
Virus-like particles are supra-molecular assemblages, usually icosahedral or rod-like
structures. They incorporate key immunologic features of viruses which include repetitive …

[HTML][HTML] Virus-like particles: Revolutionary platforms for developing vaccines against emerging infectious diseases

H Tariq, S Batool, S Asif, M Ali, BH Abbasi - Frontiers in microbiology, 2022 - frontiersin.org
Virus-like particles (VLPs) are nanostructures that possess diverse applications in
therapeutics, immunization, and diagnostics. With the recent advancements in biomedical …

Formulation and stabilization of recombinant protein based virus-like particle vaccines

NK Jain, N Sahni, OS Kumru, SB Joshi… - Advanced drug delivery …, 2015 - Elsevier
Vaccine formulation development has traditionally focused on improving antigen storage
stability and compatibility with conventional adjuvants. More recently, it has also provided an …

Adjuvant formulations for virus-like particle (VLP) based vaccines

V Cimica, JM Galarza - Clinical immunology, 2017 - Elsevier
The development of virus-like particle (VLP) technology has had an enormous impact on
modern vaccinology. In order to optimize the efficacy and safety of VLP-based vaccines …