Biochemical analysis of transcriptional activation by Jun: differential activity of c-and v-Jun

D Bohmann, R Tjian - Cell, 1989 - cell.com
The human proto-oncogene product, cJun, is a member of the AP-1 family of transcription
factors, which mediate the regulation of gene expression in response to extracellular …

jun-D: a third member of the jun gene family.

K Ryder, A Lanahan… - Proceedings of the …, 1989 - National Acad Sciences
The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine
c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth …

Characterization of junD: a new member of the jun proto‐oncogene family.

SI Hirai, RP Ryseck, F Mechta, R Bravo… - The EMBO journal, 1989 - embopress.org
In an extensive screen of a cDNA library prepared from serum‐stimulated mouse NIH 3T3
cells, we identified three distinct jun‐related clones. Two of them were carrying c‐jun and …

Both Jun and Fos contribute to transcription activation by the heterodimer.

SL Hirai, B Bourachot, M Yaniv - Oncogene, 1990 - europepmc.org
Comparison of the amino acid sequence of the three members of the mouse jun proto-
oncogene family, c-jun, jun B and jun D, reveals several homologous segments. The most C …

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

TJ Bos, D Bohmann, H Tsuchie, R Tijan, PK Vogt - Cell, 1988 - Elsevier
The jun oncogene of ASV17 is expressed as a 65 kd protein (p65 gag-jun) that contains
partial gag sequences at its amino terminus fused to jun sequences that make up the …

Activation of junB by PKC and PKA signal transduction through a novel cis-acting element

RP de Groot, J Auwerx, M Karperien… - Nucleic acids …, 1991 - academic.oup.com
The product of the junB gene, a gene homologous to the proto-oncogene c-jun, is a
component of transcription factor AP-1. JunB expression is modulated by a wide variety of …

A gene activated by growth factors is related to the oncogene v-jun.

K Ryder, LF Lau, D Nathans - Proceedings of the National …, 1988 - National Acad Sciences
We have recently identified by cDNA cloning a set of genes that are rapidly activated in
cultured mouse cells by protein growth factors. Here we report that the nucleotide sequence …

JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers.

T Deng, M Karin - Genes & development, 1993 - genesdev.cshlp.org
JunB differs considerably from c-Jun in its ability to activate AP-1-responsive genes and
induce oncogenic transformation. We demonstrate that the decreased ability of JunB to …

Induction of protooncogene c-jun by serum growth factors.

K Ryder, D Nathans - … of the National Academy of Sciences, 1988 - National Acad Sciences
We have previously reported that one of the genes that is rapidly induced in mouse 3T3 cells
by serum growth factors (jun-B) encodes a protein related to the onco-protein v-jun. By using …

Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner.

P Angel, T Smeal, J Meek, M Karin - The New Biologist, 1989 - europepmc.org
Transcription factor AP1 is a heteromeric complex composed of the Jun and Fos proteins. It
has been shown that by associating with Jun, Fos increases Jun's ability to bind DNA and …