Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications

K Sunagar, EAB Undheim, H Scheib, ECK Gren… - Journal of …, 2014 - Elsevier
Due to the extreme variation of venom, which consequently results in drastically variable
degrees of neutralization by CroFab antivenom, the management and treatment of …

Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery

SD Robinson, EAB Undheim… - Expert review of …, 2017 - Taylor & Francis
Introduction: Animal venoms are complex chemical arsenals. Most venoms are rich in
bioactive peptides with proven potential as research tools, drug leads and drugs. Areas …

Proteomic and transcriptomic techniques to decipher the molecular evolution of venoms

S Mouchbahani-Constance, R Sharif-Naeini - Toxins, 2021 - mdpi.com
Nature's library of venoms is a vast and untapped resource that has the potential of
becoming the source of a wide variety of new drugs and therapeutics. The discovery of these …

Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis

RS Rodrigues, J Boldrini-França, FPP Fonseca… - Journal of …, 2012 - Elsevier
Unraveling the repertoire of venom toxins of Bothropoides pauloensis was assessed by
snake venomics and venom gland transcriptomic surveys. Both approaches yielded …

Moving Pieces in a Venomic Puzzle: Unveiling Post-translationally Modified Toxins from Tityus serrulatus

T Verano-Braga, AAA Dutra, IR León… - Journal of proteome …, 2013 - ACS Publications
Besides being a public health problem, scorpion venoms have a potential biotechnological
application since they contain peptides that may be used as drug leads and/or to reveal …

Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)

BG Fry, H Scheib, L van der Weerd, B Young… - Molecular & Cellular …, 2008 - ASBMB
Venom is a key innovation underlying the evolution of advanced snakes (Caenophidia).
Despite this, very little is known about venom system structural diversification, toxin …

[HTML][HTML] Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

B Lomonte, JJ Calvete - Journal of Venomous Animals and Toxins …, 2017 - SciELO Brasil
This work offers a general overview on the evolving strategies for the proteomic analysis of
snake venoms, and discusses how these may be combined through diverse experimental …

Diversity of Toxic Components from the Venom of the Evolutionarily Distinct Black Whip Snake, Demansia vestigiata

L St Pierre, GW Birrell, ST Earl, TP Wallis… - Journal of proteome …, 2007 - ACS Publications
Included among the more than 300 species of elapid snakes worldwide is the Australian
genus Demansia, or whip snakes. Despite evidence to suggest adverse clinical outcomes …

Bothrops insularis venomics: a proteomic analysis supported by transcriptomic-generated sequence data

RH Valente, PR Guimarães, M Junqueira… - Journal of …, 2009 - Elsevier
A joint transcriptomic and proteomic approach employing two-dimensional electrophoresis,
liquid chromatography and mass spectrometry was carried out to identify peptides and …

Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences

BG Fry, W Wüster - Molecular biology and evolution, 2004 - academic.oup.com
We analyzed the origin and evolution of snake venom toxin families represented in both
viperid and elapid snakes by means of phylogenetic analysis of the amino acid sequences …