A perspective view of top‐down proteomics in snake venom research

P Ghezellou, V Garikapati, SM Kazemi… - Rapid …, 2019 - Wiley Online Library
The venom produced by snakes contains complex mixtures of pharmacologically active
proteins and peptides which play a crucial role in the pathophysiology of snakebite …

Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures

JW Fox, SMT Serrano - Proteomics, 2008 - Wiley Online Library
Snake venom proteomes are complex mixtures of a large number of distinct proteins. In a
sense, the field of snake venom proteomics has been under investigation since the very …

Snake venomics–from low-resolution toxin-pattern recognition to toxin-resolved venom proteomes with absolute quantification

JJ Calvete - Expert Review of Proteomics, 2018 - Taylor & Francis
Introduction: Venoms are integrated phenotypes used by a wide range of organisms for
predatory and defensive purposes. The study of venoms is of great interest in diverse fields …

[HTML][HTML] Protein-species quantitative venomics: looking through a crystal ball

JJ Calvete, D Petras, F Calderón-Celis… - Journal of Venomous …, 2017 - SciELO Brasil
In this paper we discuss recent significant developments in the field of venom research,
specifically the emergence of top-down proteomic applications that allow achieving …

Streamlining the Analysis of Proteins from Snake Venom

I Oganesyan, TP Jenkins, AH Laustsen… - Journal of Proteome …, 2024 - ACS Publications
Investigating snake venom is necessary for developing new treatments for envenoming and
harnessing the therapeutic potential that lies within venom toxins. Despite considerable …

A protein decomplexation strategy in snake venom proteomics

CH Tan, KY Tan, NH Tan - Functional Proteomics: Methods and Protocols, 2019 - Springer
Snake venoms are complex mixtures of proteins and peptides that play vital roles in the
survival of venomous snakes. As with their diverse pharmacological activities, snake …

Snake venomics. Strategy and applications

JJ Calvete, P Juárez, L Sanz - Journal of mass spectrometry, 2007 - Wiley Online Library
Snake bites can be deadly, but the venoms also contain components of medical and
biotechnological value. The proteomic characterization of snake venom proteomes, snake …

Interrogating the higher order structures of snake venom proteins using an integrated mass spectrometric approach

CR Wang, ER Bubner, B Jovcevski, P Mittal… - Journal of …, 2020 - Elsevier
Snake venoms contain complex mixtures of proteins vital for the survival of venomous
snakes. Aligned with their diverse pharmacological activities, the protein compositions of …

Unraveling snake venom complexity with 'omics' approaches: challenges and perspectives

A Zelanis, AK Tashima - Toxicon, 2014 - Elsevier
The study of snake venom proteomes (venomics) has been experiencing a burst of reports,
however the comprehensive knowledge of the dynamic range of proteins present within a …

Absolute venomics: Absolute quantification of intact venom proteins through elemental mass spectrometry

F Calderón-Celis, L Cid-Barrio, JR Encinar… - Journal of …, 2017 - Elsevier
We report the application of a hybrid element and molecular MS configuration for the parallel
absolute quantification of μHPLC-separated intact sulfur-containing venom proteins, via ICP …