[HTML][HTML] Characterisation of the forest cobra (Naja melanoleuca) venom using a multifaceted mass spectrometric-based approach

CR Wang, AC Harlington, MF Snel… - Biochimica et Biophysica …, 2024 - Elsevier
Snake venoms consist of highly biologically active proteins and peptides that are
responsible for the lethal physiological effects of snakebite envenomation. In order to guide …

Interrogating the higher order structures of snake venom proteins using an integrated mass spectrometric approach

CR Wang, ER Bubner, B Jovcevski, P Mittal… - Journal of …, 2020 - Elsevier
Snake venoms contain complex mixtures of proteins vital for the survival of venomous
snakes. Aligned with their diverse pharmacological activities, the protein compositions of …

[HTML][HTML] Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …

Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures

JW Fox, SMT Serrano - Proteomics, 2008 - Wiley Online Library
Snake venom proteomes are complex mixtures of a large number of distinct proteins. In a
sense, the field of snake venom proteomics has been under investigation since the very …

A protein decomplexation strategy in snake venom proteomics

CH Tan, KY Tan, NH Tan - Functional Proteomics: Methods and Protocols, 2019 - Springer
Snake venoms are complex mixtures of proteins and peptides that play vital roles in the
survival of venomous snakes. As with their diverse pharmacological activities, snake …

[HTML][HTML] Exploring Snake Venoms Beyond the Primary Sequence: from Proteoforms to Protein-Protein Interactions

CR Wang, LO McFarlane, TL Pukala - Toxicon, 2024 - Elsevier
Snakebite envenomation has been a long-standing global issue that is difficult to treat,
largely owing to the flawed nature of current immunoglobulin-based antivenom therapy and …

An in-depth snake venom proteopeptidome characterization: Benchmarking Bothrops jararaca

CA Nicolau, PC Carvalho… - Journal of …, 2017 - Elsevier
A large-scale proteomic approach was devised to advance the understanding of venom
composition. Bothrops jararaca venom was fractionated by OFFGEL followed by …

[HTML][HTML] Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

B Lomonte, JJ Calvete - Journal of Venomous Animals and Toxins …, 2017 - SciELO Brasil
This work offers a general overview on the evolving strategies for the proteomic analysis of
snake venoms, and discusses how these may be combined through diverse experimental …

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca

LP Lauridsen, AH Laustsen, B Lomonte… - Journal of …, 2017 - Elsevier
A toxicovenomic analysis of the venom of the forest cobra, N. melanoleuca, was performed,
revealing the presence of a total of 52 proteins by proteomics analysis. The most abundant …

Deep venomics of the Pseudonaja genus reveals inter-and intra-specific variation

T Reeks, V Lavergne, K Sunagar, A Jones… - Journal of …, 2016 - Elsevier
Australian elapid venom remains an under-investigated resource of novel bioactive
peptides. In this study, the venom gland transcriptomes and proteomes of the Australian …