Interrogating the higher order structures of snake venom proteins using an integrated mass spectrometric approach

CR Wang, ER Bubner, B Jovcevski, P Mittal… - Journal of …, 2020 - Elsevier
Snake venoms contain complex mixtures of proteins vital for the survival of venomous
snakes. Aligned with their diverse pharmacological activities, the protein compositions of …

[HTML][HTML] Characterisation of the forest cobra (Naja melanoleuca) venom using a multifaceted mass spectrometric-based approach

CR Wang, AC Harlington, MF Snel… - Biochimica et Biophysica …, 2024 - Elsevier
Snake venoms consist of highly biologically active proteins and peptides that are
responsible for the lethal physiological effects of snakebite envenomation. In order to guide …

Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures

JW Fox, SMT Serrano - Proteomics, 2008 - Wiley Online Library
Snake venom proteomes are complex mixtures of a large number of distinct proteins. In a
sense, the field of snake venom proteomics has been under investigation since the very …

A protein decomplexation strategy in snake venom proteomics

CH Tan, KY Tan, NH Tan - Functional Proteomics: Methods and Protocols, 2019 - Springer
Snake venoms are complex mixtures of proteins and peptides that play vital roles in the
survival of venomous snakes. As with their diverse pharmacological activities, snake …

An in-depth snake venom proteopeptidome characterization: Benchmarking Bothrops jararaca

CA Nicolau, PC Carvalho… - Journal of …, 2017 - Elsevier
A large-scale proteomic approach was devised to advance the understanding of venom
composition. Bothrops jararaca venom was fractionated by OFFGEL followed by …

A perspective view of top‐down proteomics in snake venom research

P Ghezellou, V Garikapati, SM Kazemi… - Rapid …, 2019 - Wiley Online Library
The venom produced by snakes contains complex mixtures of pharmacologically active
proteins and peptides which play a crucial role in the pathophysiology of snakebite …

Comparison of indirect and direct approaches using ion-trap and Fourier transform ion cyclotron resonance mass spectrometry for exploring viperid venom proteomes

JW Fox, L Ma, K Nelson, NE Sherman, SMT Serrano - Toxicon, 2006 - Elsevier
In a sense, the field of snake venom proteomics has been under investigation since the very
earliest biochemical studies where it was soon recognized that venoms are comprised of …

Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …

Streamlining the Analysis of Proteins from Snake Venom

I Oganesyan, TP Jenkins, AH Laustsen… - Journal of Proteome …, 2024 - ACS Publications
Investigating snake venom is necessary for developing new treatments for envenoming and
harnessing the therapeutic potential that lies within venom toxins. Despite considerable …

The Diversity of Bioactive Proteins in Australian Snake Venoms* S

GW Birrell, STH Earl, TP Wallis, PP Masci… - Molecular & Cellular …, 2007 - ASBMB
Australian elapid snakes are among the most venomous in the world. Their venoms contain
multiple components that target blood hemostasis, neuromuscular signaling, and the …