Safety and efficacy of oral direct inhibitors of thrombin and factor Xa in antiphospholipid syndrome

N Noel, F Dutasta, N Costedoat-Chalumeau… - Autoimmunity …, 2015 - Elsevier
Background Long-term anticoagulation is recommended in antiphospholipid syndrome with
thrombosis in order to prevent recurrences. While the current mainstay relies on vitamin K …

Recurrent thrombosis with direct oral anticoagulants in antiphospholipid syndrome: a systematic literature review and meta-analysis

J Sanchez-Redondo, G Espinosa, DV Delgado… - Clinical …, 2019 - Elsevier
Purpose The treatment of thrombosis in patients with antiphospholipid syndrome (APS)
usually requires long-term anticoagulation with vitamin K antagonists. The effectiveness of …

Increased risk of thrombosis in antiphospholipid syndrome patients treated with direct oral anticoagulants. Results from an international patient-level data meta …

V Dufrost, J Risse, T Reshetnyak, M Satybaldyeva… - Autoimmunity …, 2018 - Elsevier
Abstract Background Direct oral anticoagulants (DOACs) are widely used for secondary
prevention of venous thromboembolism (VTE) but their clinical efficacy and safety are not …

Direct oral anticoagulants in antiphospholipid syndrome: meta-analysis of randomized controlled trials

V Dufrost, D Wahl, S Zuily - Autoimmunity reviews, 2021 - Elsevier
Background The gold standard for secondary thromboprophylaxis in APS is long term
anticoagulation with vitamin K antagonists (VKAs). Because of their widespread use and …

Factor Xa inhibitors for preventing recurrent thrombosis in patients with antiphospholipid syndrome: a longitudinal cohort study

T Sato, H Nakamura, Y Fujieda, N Ohnishi, N Abe… - Lupus, 2019 - journals.sagepub.com
Objective The objective of this study was to clarify the efficacy and safety of factor Xa
inhibitors for antiphospholipid syndrome patients in real world utilization. Methods This is a …

Direct oral anticoagulants: an alternative treatment for thrombotic antiphospholipid syndrome?

AS Resseguier, B Pereira, V Rieu, G Le Guenno… - Lupus, 2017 - journals.sagepub.com
Background Direct oral anticoagulants (DOACs) demonstrate a lower risk–benefit ratio than
vitamin K antagonists (VKAs) for secondary thromboprophylaxis of thrombotic events. But …

Direct oral anticoagulants use in antiphospholipid syndrome: are these drugs an effective and safe alternative to warfarin? A systematic review of the literature

V Dufrost, J Risse, S Zuily, D Wahl - Current rheumatology reports, 2016 - Springer
Background The cornerstone of thrombotic antiphospholipid syndrome (APS) patients'
management is to prevent recurrent thrombosis by long-term anticoagulation. Purpose of …

Anticoagulation withdrawal in antiphospholipid syndrome: a retrospective matched-control study

CM Yelnik, G Urbanski, E Drumez, C Caron… - Lupus, 2018 - journals.sagepub.com
Background/Purpose Long-term anticoagulation is the standard treatment for thrombotic
antiphospholipid syndrome (APS). However, in daily practice, the question of withdrawing …

Direct oral anticoagulants in antiphospholipid syndrome: a real life case series

JF Betancur, F Bonilla-Abadía, AA Hormaza… - Lupus, 2016 - journals.sagepub.com
Aim The aim of this study was to describe a case series of patients with primary or secondary
antiphospholipid syndrome (APS) treated with direct oral anticoagulants (DOACs). Patients …

[HTML][HTML] Use of direct oral anticoagulants in antiphospholipid syndrome

H Cohen, M Efthymiou, DA Isenberg - Journal of Thrombosis and …, 2018 - Elsevier
The direct oral anticoagulants (DOACs) are therapeutic alternatives to warfarin and other
vitamin K antagonists (VKAs), and constitute the standard of care for many indications. VKAs …