Snake venomics–from low-resolution toxin-pattern recognition to toxin-resolved venom proteomes with absolute quantification

JJ Calvete - Expert Review of Proteomics, 2018 - Taylor & Francis
Introduction: Venoms are integrated phenotypes used by a wide range of organisms for
predatory and defensive purposes. The study of venoms is of great interest in diverse fields …

Next-generation snake venomics: protein-locus resolution through venom proteome decomplexation

JJ Calvete - Expert review of proteomics, 2014 - Taylor & Francis
Venom research has been continuously enhanced by technological advances. High-
throughput technologies are changing the classical paradigm of hypothesis-driven research …

Venomics: integrative venom proteomics and beyond

JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

Exploring snake venom proteomes: multifaceted analyses for complex toxin mixtures

JW Fox, SMT Serrano - Proteomics, 2008 - Wiley Online Library
Snake venom proteomes are complex mixtures of a large number of distinct proteins. In a
sense, the field of snake venom proteomics has been under investigation since the very …

[HTML][HTML] Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Unraveling snake venom complexity with 'omics' approaches: challenges and perspectives

A Zelanis, AK Tashima - Toxicon, 2014 - Elsevier
The study of snake venom proteomes (venomics) has been experiencing a burst of reports,
however the comprehensive knowledge of the dynamic range of proteins present within a …

Integration of transcriptomic and proteomic approaches for snake venom profiling

CM Modahl, AJ Saviola… - Expert Review of …, 2021 - Taylor & Francis
Introduction Snake venoms contain many protein and peptide isoforms with high levels of
sequence variation, even within a single species. Areas covered In this review, we highlight …

[HTML][HTML] Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …

Absolute venomics: Absolute quantification of intact venom proteins through elemental mass spectrometry

F Calderón-Celis, L Cid-Barrio, JR Encinar… - Journal of …, 2017 - Elsevier
We report the application of a hybrid element and molecular MS configuration for the parallel
absolute quantification of μHPLC-separated intact sulfur-containing venom proteins, via ICP …

A perspective view of top‐down proteomics in snake venom research

P Ghezellou, V Garikapati, SM Kazemi… - Rapid …, 2019 - Wiley Online Library
The venom produced by snakes contains complex mixtures of pharmacologically active
proteins and peptides which play a crucial role in the pathophysiology of snakebite …