Postsynaptic density 95 (PSD-95) is a major synaptic scaffolding protein that plays a key role
in bidirectional synaptic plasticity, which is a process important for learning and memory. It is …

Dendritic morphology determines many aspects of neuronal function, including action
potential propagation and information processing. However, the question remains as to how …

PSD-95, a principal scaffolding component of the postsynaptic density, is targeted to
synapses by palmitoylation, where it couples NMDA receptor stimulation to production of …

PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

Neurons differentially localize and cluster membrane proteins. Spatial localization and
clustering of ion channels and neurotransmitter receptors are necessary for neurons to fire …

The postsynaptic density protein of 95 kDa (PSD-95) is a key scaffolding protein that controls
signaling at synapses in the brain through interactions of its PDZ domains with the C-termini …

Single-particle electron microscopy (EM) combined with biochemical measurements
revealed the molecular shape of SAP97 and a monomer-dimer transition that depended on …

Distinct PSD-95 clusters are primary landmarks of postsynaptic densities (PSDs), which are
specialized membrane regions for synapses. However, the mechanism that defines the …

The activity-dependent regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …

PSD-95 (postsynaptic density 95) is a postsynaptic scaffolding protein that links NMDA
receptors to the cytoskeleton and signaling molecules. The N-terminal domain of PSD-95 is …