Insights into the mechanisms underlying colonic motor patterns

NJ Spencer, PG Dinning, SJ Brookes… - The Journal of …, 2016 - Wiley Online Library
In recent years there have been significant technical and methodological advances in our
ability to record the movements of the gastrointestinal tract. This has led to significant …

Advances in colonic motor complexes in mice

NJ Spencer, M Costa, TJ Hibberd… - American Journal of …, 2021 - journals.physiology.org
The primary functions of the gastrointestinal (GI) tract are to absorb nutrients, water, and
electrolytes that are essential for life. This is accompanied by the capability of the GI tract to …

The enteric nervous system and regulation of intestinal motility

WAA Kunze, JB Furness - Annual review of physiology, 1999 - annualreviews.org
▪ Abstract The enteric nervous system exerts local control over mixing and propulsive
movements in the small intestine. When digestion is in progress, intrinsic primary afferent …

Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis

PG Dinning, L Wiklendt, T Omari… - Frontiers in …, 2014 - frontiersin.org
Propulsive contractions of circular muscle are largely responsible for the movements of
content along the digestive tract. Mechanical and electrophysiological recordings of isolated …

An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility

M Costa, L Wiklendt, JW Arkwright… - Frontiers in systems …, 2013 - frontiersin.org
Excitatory and inhibitory enteric neural input to intestinal muscle acting on ongoing
myogenic activity determines the rich repertoire of motor patterns involved in digestive …

Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal

SD Koh, BT Drumm, H Lu, HJ Kim… - Proceedings of the …, 2022 - National Acad Sciences
The peristaltic reflex is a fundamental behavior of the gastrointestinal (GI) tract in which
mucosal stimulation activates propulsive contractions. The reflex occurs by stimulation of …

Colonic elongation inhibits pellet propulsion and migrating motor complexes in the murine large bowel

DJ Heredia, EJ Dickson, PO Bayguinov… - The Journal of …, 2010 - Wiley Online Library
The colonic migrating motor complex (CMMC) is a rhythmically occurring neurally mediated
motor pattern. Although the CMMC spontaneously propagates along an empty colon it is …

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

NJ Spencer, H Hu - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
The gastrointestinal tract is the only internal organ to have evolved with its own independent
nervous system, known as the enteric nervous system (ENS). This Review provides an …

Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high‐resolution fiber‐optic manometry

PG Dinning, L Wiklendt, L Maslen… - …, 2014 - Wiley Online Library
Background Until recently, investigations of the normal patterns of motility of the healthy
human colon have been limited by the resolution of in vivo recording techniques. Methods …

Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies

SJ Brookes, PG Dinning… - Neurogastroenterology & …, 2009 - Wiley Online Library
Colorectal physiology is complex and involves programmed, coordinated interaction
between muscular and neuronal elements. Whilst a detailed understanding remains elusive …