Plasmodium circumsporozoite (CS) protein-induced antibody and T-cell responses are
considered to be important in protective immunity. Since the key repeat determinant of the …

Seventeen malaria-naive volunteers received a recombinant Plasmodium falciparum
vaccine (RLF) containing the carboxy-and the amino-terminal of the circumsporozoite …

Immunization of mice with irradiated malaria sporozoites induces protection that is
dependent on CD8+ T cells, and adoptive transfer of CD8+ cytotoxic T lymphocyte (CTL) …

Liposomes containing lipid A have been developed as adjuvants for inducing humoral
immunity to synthetic antigens containing repeat sequence epitopes from the …

A liposome-encapsulated cloned protein (R32tet32) containing sequences from the
tetrapeptide repeat region of the circumsporozoite protein of Plasmodium falciparum …

This study describes the safety and immunogenicity of a liposome-based vaccine injected
into human subjects. Thirty healthy adult male volunteers were immunized with a liposome …

Minutes after injection into the circulation, malaria sporozoites enter hepatocytes. The speed
and specificity of the invasion process suggest that it is receptor mediated. The region II …

A vaccine targeting multiple stages of the Plasmodium falciparum parasite life cycle is
desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading …

The N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in
the search for a malaria vaccine in spite of being a target of inhibitory antibodies and …

An effective malaria vaccine is needed to address the public health tragedy resulting from
the high levels of morbidity and mortality caused by Plasmodium parasites. The first …