Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of …
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by impairments in social communication and social interaction and the presence of repetitive …
AB Arnett, S Trinh, RA Bernier - Current opinion in psychology, 2019 - Elsevier
Highlights•Heterogeneity in autism spectrum disorder presents a challenge to clinical care and research.•Genetic sequencing indicates disruptive gene variants and CNVs account for …
M Woodbury‐Smith, SW Scherer - Developmental Medicine & …, 2018 - Wiley Online Library
A genetic basis for autism spectrum disorder (ASD) is now well established, and with the availability of high‐throughput microarray and sequencing platforms, major advances have …
Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their risk effects are highly variable, and they are frequently related to other conditions besides …
AR Gupta, MW State - Biological psychiatry, 2007 - Elsevier
Autism is a strongly genetic disorder, with an estimated heritability of greater than 90%. Nonetheless, its specific genetic etiology remains largely unknown. Over the past several …
Although genes have long been appreciated to play a critical role in determining the risk for pervasive developmental disorders, the specific transcripts contributing to autism spectrum …
Highlights•High throughput genomic methods are rapidly increasing the pool of ASD genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …
ME Talkowski, EV Minikel… - Harvard review of …, 2014 - journals.lww.com
The last several years have seen unprecedented advances in deciphering the genetic etiology of autism spectrum disorders (ASDs). Heritability studies have repeatedly affirmed a …