Malaria caused by Plasmodium falciparum remains a major public health threat, especially
among children and pregnant women in Africa. An effective malaria vaccine would be a …

RTS, S is the most advanced candidate vaccine against human malaria. During its
remarkable journey from conception and design in the early 1980s to the multicenter Phase …

RTS, S is the world's most advanced malaria vaccine candidate and is intended to protect
infants and young children living in malaria endemic areas of sub‐Saharan Africa against …

Abstract Background The RTS, S malaria vaccine is currently undergoing phase 3 trials.
High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have …

T-cell-mediated responses against the liver-stage of Plasmodium falciparum are critical for
protection in the human irradiated sporozoite model and several animal models …

Scientists hail historic malaria vaccine approval - but point to challenges ahead. - Abstract -
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Naturally acquired immunity to the blood-stage of the malaria parasite develops slowly in
areas of high endemicity, but is not sterilizing. It manifests as a reduction in parasite density …

Malaria vaccine development aims to significantly reduce mortality and morbidity in the two
high-risk groups: young children and pregnant women in sub-Saharan Africa. A pre …

Summary Background The RTS, S/AS01 E candidate malaria vaccine is being developed for
immunisation of infants in Africa through the expanded programme on immunisation (EPI). 8 …

Introduction Mass malaria vaccination, rather than vaccinating only children below age 5,
has been proven to have the potential to reduce morbidity and mortality among those …