A vaccine targeting multiple stages of the Plasmodium falciparum parasite life cycle is
desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading …

The circumsporozoite protein (CSP) of Plasmodium falciparum is a major surface protein,
which forms a dense coat on the sporozoite's surface. Preclinical research on CSP and …

A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …

The induction of protective humoral immune responses against sporozoite surface proteins
of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a …

Plasmodium circumsporozoite (CS) protein-induced antibody and T-cell responses are
considered to be important in protective immunity. Since the key repeat determinant of the …

Malaria caused by Plasmodium falciparum continues to threaten millions of people living in
the tropical parts of the world. A vaccine that confers sterile and life-long protection remains …

Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …

RTS, S is the leading malaria vaccine in development, but has demonstrated only moderate
protective efficacy in clinical trials. RTS, S is a virus-like particle (VLP) that uses the human …

Despite several decades of extensive research, the development of a highly efficacious
malaria vaccine has yet to be accomplished. While the RTS, S malaria vaccine candidate …

Background Plasmodium circumsporozoite protein (CSP) is a major surface antigen present
in the sporozoite (Spz) stage of a malaria parasite. RTS, S vaccine, the most clinically …