Despite decades of research, malaria remains a global health crisis. Current subunit vaccine
approaches do not provide efficient long-term, sterilizing immunity against Plasmodium …

Background The continuing morbidity and mortality associated with infection with malaria
parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in …

Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

The development of a vaccine is essential for the elimination of malaria. However, despite
many years of effort, a successful vaccine has not been achieved. Most subunit vaccine …

Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

The development of an efficacious Plasmodium falciparum malaria vaccine remains a top
priority for global health. Vaccination with irradiated sporozoites is able to provide complete …

Malaria is a life-threatening disease caused by infection with Plasmodium parasites. The
goal of developing an effective malaria vaccine is yet to be reached despite decades of …

Despite nearly 100 years of research and control efforts, malaria remains one of the most
important infectious diseases. An efficient vaccine would be a powerful to tool to reduce …

Evidence accumulated through the years clearly indicates that antiparasite immune
responses can efficiently control malaria parasite infection at all development stages, and …

Vaccine development for the blood stages of malaria has focused on the induction of
antibodies to parasite surface antigens, most of which are highly polymorphic. An alternate …