An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

The immune system has adapted to effect different mechanisms to combat the multitude of
potential pathogens in our environment. In particular, CD8 T cells are participants in the …

CD8 T cells are an important part of the adaptive immune system providing protection
against intracellular bacteria, viruses, and protozoa. After infection and/or vaccination …

Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration
of antigenic, co‐stimulatory and inflammatory signals undergo a programmed series of …

Immunological memory is one of the features that define the adaptive immune response: by
generating specific memory cells after infection or vaccination, the host provides itself with a …

Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …

CD8 T cells contribute to clearance and long-term protection following acute infection with
certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity …

CD4 T-cell memory is in some ways more enigmatic than CD8 T-cell memory. This is mostly
due to the fact that CD4 T cells tend to expand far less in response to antigenic stimuli …