Dynamic co-evolution of host and pathogen: HCMV downregulates the prevalent allele MICA∗ 008 to escape elimination by NK cells
Natural killer (NK) cells mediate innate immune responses against hazardous cells and are
particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK …
particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK …
The human cytomegalovirus protein UL148A downregulates the NK cell-activating ligand MICA to avoid NK cell attack
Natural killer (NK) cells are lymphocytes of the innate immune system capable of killing
hazardous cells, including virally infected cells. NK cell-mediated killing is triggered by …
hazardous cells, including virally infected cells. NK cell-mediated killing is triggered by …
The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA* 008, to evade NK cell-mediated killing
E Seidel, L Dassa, C Schuler, E Oiknine-Djian… - PLoS …, 2021 - journals.plos.org
Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells without
prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of …
prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of …
Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation
CA Fielding, R Aicheler, RJ Stanton, ECY Wang… - PLoS …, 2014 - journals.plos.org
NKG2D plays a major role in controlling immune responses through the regulation of natural
killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct …
killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct …
Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142
NJ Chalupny, A Rein-Weston, S Dosch… - … and biophysical research …, 2006 - Elsevier
Human cytomegalovirus (HCMV) employs a variety of strategies to modify or evade the host
immune response, and natural killer (NK) cells play a crucial role in controlling …
immune response, and natural killer (NK) cells play a crucial role in controlling …
All is fair in virus–host interactions: NK cells and cytomegalovirus
The infection of mice with mouse cytomegalovirus (MCMV) as a model of human
cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of …
cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of …
Natural killer cell evasion is essential for infection by rhesus cytomegalovirus
ER Sturgill, D Malouli, SG Hansen, BJ Burwitz… - PLoS …, 2016 - journals.plos.org
The natural killer cell receptor NKG2D activates NK cells by engaging one of several ligands
(NKG2DLs) belonging to either the MIC or ULBP families. Human cytomegalovirus (HCMV) …
(NKG2DLs) belonging to either the MIC or ULBP families. Human cytomegalovirus (HCMV) …
Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their α2 domains
J Spreu, T Stehle, A Steinle - The Journal of Immunology, 2006 - journals.aai.org
Human CMV infection results in MHC class I down-regulation and induction of NKG2D
ligand expression favoring NK recognition of infected cells. However, human CMV-encoded …
ligand expression favoring NK recognition of infected cells. However, human CMV-encoded …
The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60–NKG2D interactions
MB Lodoen, G Abenes, S Umamoto… - The Journal of …, 2004 - rupress.org
Natural killer (NK) cells are an important early mediator of host immunity to murine
cytomegalovirus (MCMV) infection. However, MCMV has evolved mechanisms to elude …
cytomegalovirus (MCMV) infection. However, MCMV has evolved mechanisms to elude …
Modulation of natural killer cells by human cytomegalovirus
Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is
under intense, continuous selective pressure from the immune system. A key aspect of …
under intense, continuous selective pressure from the immune system. A key aspect of …