Parasitic protozoa cause considerable disease in humans and, due to their intracellular life
cycle, induce robust CD8+ T cell responses. A greater understanding of the factors that …

Protection against liver-stage malaria relies on the induction of high frequencies of antigen-
specific CD8+ T cells. We have previously reported high protective levels against mouse …

Understanding protective immunity to malaria is essential for the design of an effective
vaccine to prevent the large number of infections and deaths caused by this parasitic …

Malaria is a major health problem as nearly half of the human population is exposed to this
parasite causing around 600 million clinical cases annually. Prime-boost regimes using …

A vaccine that elicits both specific antibodies and IFN-γ-producing T cells is required to
protect against pre-erythrocytic malaria. Among the most promising approaches to induce …

To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection,
we generated an MHC I-restricted TCR transgenic mouse line against this pathogen. T cells …

Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill
Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination …

Highlights•Natural malaria infections induce suboptimal memory CD8 T cell
responses.•Natural malaria infections do not induce sterilizing immunity.•Immunization with …

Since malaria continues to account for millions of deaths annually in endemic regions, the
development of an effective vaccine remains highly desirable. The life cycle of malaria …

Identification of correlates of protection for infectious diseases including malaria is a major
challenge and has become one of the main obstacles in developing effective vaccines. We …