Vaccination with a single dose of genetically attenuated malaria parasites can induce sterile
protection against sporozoite challenge in the rodent Plasmodium yoelii model. Protection is …

Immunization with attenuated whole Plasmodium sporozoites constitutes a promising
vaccination strategy. Compared to replication-deficient parasites, immunization with …

Sterile immunity against live Plasmodium infection can be achieved by immunization with
radiation-attenuated sporozoites. This protection is known to be mediated in part by antigen …

The worldwide burden of malaria can be substantially reduced using existing public health
interventions. However, elimination of Plasmodium will require fundamentally different …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected
cells and prevent malaria, but simple vaccines for generating this important immune …

Malaria, caused by Plasmodium parasite infection, continues to be one of the leading
causes of worldwide morbidity and mortality. Development of an effective vaccine has been …

Sterile protective immunity against challenge with Plasmodium spp. sporozoites can be
induced in multiple model systems and humans by immunization with radiation-attenuated …

Abstract Malaria results in> 1,000,000 deaths per year worldwide. Although no licensed
vaccine exists, much effort is currently focused on subunit vaccines that elicit CD8 T cell …

Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with …