In humans and murine models of malaria, intradermal immunization (ID-I) with genetically
attenuated sporozoites that arrest in liver induces lower protective immunity than …

The difficulty of inducing protective immunity through antibodies against sporozoites led to
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …

While the role of malaria parasite-specific memory CD8+ T cells in the control of exo-
erythrocytic stages of malaria infection is well documented and generally accepted, a debate …

Developing a modern vaccine that is able to duplicate the protective immunity observered
after immunization with irradiated P. falciparum (Pf) sporozoites requires identification of …

Background The continuing morbidity and mortality associated with infection with malaria
parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in …

Each year over 200 million malaria infections occur, with over 400 000 associated deaths.
Vaccines formed with attenuated whole parasites can induce protective memory CD8 T cell …

Whole-parasite malaria vaccines have shown promise in clinical trials. We recently reported
the first human trial of a malaria vaccine based on Plasmodium falciparum genetically …

Advances in our understanding of the molecular and cell biology of the malaria parasite
have led to new vaccine development efforts resulting in a pipeline of over 40 candidates …

Since the demonstration of sterile protection afforded by injection of irradiated sporozoites,
CD8+ T cells have been shown to play a significant role in protection from liver-stage …

The complex life cycle of the malaria parasite involves several developmental stages in the
mammalian host that provide opportunities for yaccine intervention. The effector arm of the …