The success of immunization with irradiated sporozoites is unparalleled among the current
vaccination approaches against malaria, but its mechanistic underpinnings have yet to be …

Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce
sterilizing protection against malaria in both humans and rodents. Importantly, these “whole …

Liver-stage development of Plasmodium parasites represents a dramatic expansion phase
for the malarial parasite between vector transmission and onset of the pathogenic blood …

For some diseases, successful vaccines have been developed using a nonpathogenic
counterpart of the causative microorganism of choice. The nonpathogenicity of the rodent …

Development of a vaccine that targets blood-stage malaria parasites is imperative if we are
to sustainably reduce the morbidity and mortality caused by this infection. Such a vaccine …

Malaria is a highly prevalent disease caused by infection by Plasmodium spp., which infect
hepatocytes and erythrocytes. Blood-stage infections cause devastating symptoms and can …

The majority of routinely given vaccines require two or three immunisations for full protective
efficacy. Single dose vaccination has long been considered a key solution to improving the …

The development of a highly efficacious and durable vaccine for malaria remains a top
priority for global health researchers. Despite the huge rise in recognition of malaria as a …

A malaria vaccine that prevents infection will be an important new tool in continued efforts of
malaria elimination, and such vaccines are under intense development for the major human …

An effective vaccine against malaria is urgently required to relieve the immense human
suffering and mortality caused by this parasite. A successful subunit vaccine against the liver …