One target of protective immunity against the Plasmodium liver stage in BALB/c mice is
represented by the circumsporozoite protein (CSP), and mainly involves its recognition by …

Protection against malaria through vaccination is known to be achievable, as first
demonstrated over 30 years ago. Vaccination via repeated bites with Plasmodium …

Background Clinically protective malaria vaccines consistently fail to protect adults and
children in endemic settings, and at best only partially protect infants. Methodology/Principal …

Whole malaria sporozoite vaccine regimens are promising new strategies, and some
candidates have demonstrated high rates of durable clinical protection associated with …

Live attenuated malaria vaccines are more potent than the recombinant protein, bacterial or
viral platform vaccines that have been tested, and an attenuated sporozoite vaccine against …

We generated T cell receptor transgenic mice specific for the liver stages of the rodent
malaria parasite Plasmodium yoelii and studied the early events in the development of in …

Background Gene-based vaccination using prime/boost regimens protects animals and
humans against malaria, inducing cell-mediated responses that in animal models target liver …

Due to the fact that the life cycle of malaria parasites is complex, undergoing both an
extracellular and intracellular phases in its host, the human immune system has to mobilize …

Eukaryotic pathogens typically follow a complex life cycle, including host switch and
morphologically distinct forms. Parasite stage conversion offers exceptional opportunities for …

Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-
induced T cells, but no subunit vaccination approach based on cellular immunity has shown …