Background Immunization with radiation-attenuated sporozoites (RAS) by mosquito bite
provides> 90% sterile protection against Plasmodium falciparum (Pf) malaria in humans …

Immunization with attenuated Plasmodium sporozoites or viral vectored vaccines can induce
protective CD8+ T cells that can find and eliminate liver-stage malaria parasites. A key …

Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as
blood-stage malaria. Here we show that a recombinant adenovirus–poxvirus prime-boost …

Despite the significant gains made with control efforts, malaria continues to be a dominant
infectious disease threat in many parts of the world [1]. Malaria in humans is caused by …

Naturally acquired immunity to the blood-stage of the malaria parasite develops slowly in
areas of high endemicity, but is not sterilizing. It manifests as a reduction in parasite density …

Malaria sexual stage and mosquito transmission-blocking vaccines (SSM-TBV) have
recently gained prominence as a necessary tool for malaria eradication. SSM-TBVs are …

Viral vectors used in heterologous prime-boost regimens are one of very few vaccination
approaches that have yielded significant protection against controlled human malaria …

During the pre-erythrocytic asymptomatic phase of malarial infection, sporozoites develop
transiently inside less than 100 hepatocytes that subsequently release thousands of …

T cells are important in the immune response to malaria, both for their cytokines and their
help for antibody production. To look at the relative importance of these roles, a T-cell …

A highly efficacious malaria vaccine that prevents disease and breaks the cycle of infection
remains an aspirational goal of medicine. Whole parasite vaccines based on the sporozoite …