Immunologic memory induced by pathogenic agents or vaccinations is inextricably linked to
long-lasting protection. Adequately maintained memory T and B cell pools assure a fast …

Sporozoite vaccination of both humans and rodents elicits potent anti-malarial immunity, but
the dose of sporozoites and the number of immunizations required varies with vaccination …

Although the malaria parasite was discovered more than 120 years ago, it is only during the
past 20 years, following the cloning of malaria genes, that we have been able to think …

Plasmodium spp.-infected mosquitos inject sporozoites into the skin of a mammalian host
during a blood meal. These enter the host's circulatory system and establish an infection in …

Protecting against both liver and blood stages of infection is a long-sought goal of malaria
vaccine design. Recently, we described the use of replication-defective viral vaccine vectors …

Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver
stages and the disease-causing blood stages of the human malaria parasite Plasmodium …

Abstract Apical membrane Ag 1 (AMA1) is one of the leading candidate Ags for inclusion in
a subunit vaccine against blood-stage malaria. However, the efficacy of Ab-inducing …

Subunit vaccination modalities tend to induce particular immune effector responses. Viral
vectors are well known for their ability to induce strong T cell responses, while protein …

Liver-resident memory CD8+ T (T RM) cells remain in and constantly patrol the liver to elicit
rapid immunity upon antigen encounter and can mediate efficient protection against liver …

Immunity to malaria has long been thought to be stage-specific. In this study we show that
immunization of BALB/c mice with live erythrocytes infected with nonlethal strains of …