Intracellular sequestration of the NKG2D ligand ULBP3 by human cytomegalovirus

NJ Bennett, O Ashiru, FJE Morgan, Y Pang… - The Journal of …, 2010 - journals.aai.org
Human CMV (HCMV) encodes multiple genes that control NK cell activation and cytotoxicity.
Some of these HCMV-encoded gene products modulate NK cell activity as ligands …

Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP) 1 and ULBP2 is …

A Rölle, M Mousavi-Jazi, M Eriksson… - The Journal of …, 2003 - journals.aai.org
Human CMV (HCMV) interferes with NK cell functions at various levels. The HCMV
glycoprotein UL16 binds some of the ligands recognized by the NK-activating receptor …

Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142

NJ Chalupny, A Rein-Weston, S Dosch… - … and biophysical research …, 2006 - Elsevier
Human cytomegalovirus (HCMV) employs a variety of strategies to modify or evade the host
immune response, and natural killer (NK) cells play a crucial role in controlling …

Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein

SA Welte, C Sinzger, SZ Lutz… - European journal of …, 2003 - Wiley Online Library
Human cytomegalovirus (HCMV) has evolved a multitude of molecular mechanisms to
evade the antiviral immune defense of the host. Recently, using soluble recombinant …

Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein

J Wu, NJ Chalupny, TJ Manley, SR Riddell… - The Journal of …, 2003 - journals.aai.org
Infection by human CMV induces expression of the cellular MHC class I-related chain A
(MICA) and chain B (MICB) surface proteins, which function as ligands for the activating …

Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein

M Hasan, A Krmpotic, Z Ruzsics, I Bubic… - Journal of …, 2005 - Am Soc Microbiol
Both human and mouse cytomegaloviruses (CMVs) encode proteins that inhibit the
activation of NK cells by down-regulating cellular ligands for the activating NK cell receptor …

Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity

C Dunn, NJ Chalupny, CL Sutherland… - The Journal of …, 2003 - rupress.org
The activating receptor, NKG2D, is expressed on a variety of immune effector cells and
recognizes divergent families of major histocompatibility complex (MHC) class I–related …

NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145

A Krmpotic, M Hasan, A Loewendorf, T Saulig… - The Journal of …, 2005 - rupress.org
The NK cell–activating receptor NKG2D interacts with three different cellular ligands, all of
which are regulated by mouse cytomegalovirus (MCMV). We set out to define the viral gene …

NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142

O Ashiru, NJ Bennett, LH Boyle, M Thomas… - Journal of …, 2009 - Am Soc Microbiol
Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression
of major histocompatibility complex (MHC) class I and II molecules on the surfaces of …

Murine cytomegalovirus regulation of NKG2D ligands

T Lenac, J Arapović, L Traven, A Krmpotić… - Medical microbiology and …, 2008 - Springer
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes morbidity risk in
immunologically suppressed and immunodeficient patients including congenital infections …