Virus‐like particle engineering: from rational design to versatile applications

X Ding, D Liu, G Booth, W Gao, Y Lu - Biotechnology Journal, 2018 - Wiley Online Library
As mimicking natural virus structures, virus‐like particles (VLPs) have evolved to become a
widely accepted technology used for humans which are safe, highly efficacious, and …

Engineering virus-like particles for antigen and drug delivery

BD Hill, A Zak, E Khera, F Wen - Current Protein and Peptide …, 2018 - ingentaconnect.com
Virus-like particles (VLPs) are nanoscale biological structures consisting of viral proteins
assembled in a morphology that mimic the native virion but do not contain the viral genetic …

Rational design of virus-like particles for nanomedicine

W Shan, C Wang, H Chen, L Ren - Accounts of Materials …, 2023 - ACS Publications
Conspectus With a plethora of advances in nanotechnology and biotechnology, the
development of natural particle-based drug delivery vectors is a rapidly emerging field; …

The role of virus-like particles in medical biotechnology

M Comas-Garcia, M Colunga-Saucedo… - Molecular …, 2020 - ACS Publications
Virus-like particles (VLPs) are protein-based, nanoscale, self-assembling, cage
architectures, which have relevant applications in biomedicine. They can be used for the …

Bioengineering virus‐like particles as vaccines

LHL Lua, NK Connors, F Sainsbury… - Biotechnology and …, 2014 - Wiley Online Library
Virus‐like particle (VLP) technology seeks to harness the optimally tuned immunostimulatory
properties of natural viruses while omitting the infectious trait. VLPs that assemble from a …

Virus-like particles: fundamentals and biomedical applications

JL Mejía-Méndez, R Vazquez-Duhalt… - International journal of …, 2022 - mdpi.com
Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for
industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self …

Towards the preparative and large-scale precision manufacture of virus-like particles

LK Pattenden, APJ Middelberg, M Niebert… - Trends in …, 2005 - cell.com
Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but
their potential has yet to be fully realized. This is because existing laboratory processes …

Biomolecular engineering of virus-like particles aided by computational chemistry methods

L Zhang, LHL Lua, APJ Middelberg, Y Sun… - Chemical Society …, 2015 - pubs.rsc.org
Virus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an
appropriate physicochemical environment. VLPs can stimulate both innate and adaptive …

Virus-like particles for drug delivery: a review of methods and applications

B Ikwuagwu, D Tullman-Ercek - Current Opinion in Biotechnology, 2022 - Elsevier
Highlights•Virus-like particles (VLPs) are versatile structuresfor drug-delivery applications.•
Mutations to VLP structural proteins can improve VLP drug delivery.•VLP–cargo loading …

Virus-like particles as antiviral vaccine: mechanism, design, and application

L Zhang, W Xu, X Ma, XJ Sun, JB Fan… - Biotechnology and …, 2023 - Springer
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not
contain viral genetic materials. They are safe and effective immune stimulators and play …