Protective immunity to liver‐stage malaria

LE Holz, D Fernandez‐Ruiz… - Clinical & translational …, 2016 - Wiley Online Library
Despite decades of research and recent clinical trials, an efficacious long‐lasting
preventative vaccine for malaria remains elusive. This parasite infects mammals via …

Prime and target immunization protects against liver-stage malaria in mice

A Gola, D Silman, AA Walters, S Sridhar… - Science translational …, 2018 - science.org
Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

[HTML][HTML] Cross-stage immunity for malaria vaccine development

W Nahrendorf, A Scholzen, RW Sauerwein… - Vaccine, 2015 - Elsevier
A vaccine against malaria is urgently needed for control and eventual eradication. Different
approaches are pursued to induce either sterile immunity directed against pre-erythrocytic …

[HTML][HTML] Towards a blood-stage vaccine for malaria: are we following all the leads?

MF Good - Nature Reviews Immunology, 2001 - nature.com
Although the malaria parasite was discovered more than 120 years ago, it is only during the
past 20 years, following the cloning of malaria genes, that we have been able to think …

Building better T‐cell‐inducing malaria vaccines

SM Todryk, M Walther - Immunology, 2005 - Wiley Online Library
Since malaria continues to account for millions of deaths annually in endemic regions, the
development of an effective vaccine remains highly desirable. The life cycle of malaria …

[PDF][PDF] Vaccination against malaria: targets, strategies and potentiation of immunity to blood stage parasites

AW Taylor-Robinson - Front Biosci, 2000 - article.imrpress.com
[Frontiers in Bioscience 5, e16-29 January 1, 2000] 16 VACCINATION AGAINST MALARIA:
TARGETS, STRATEGIES AND POTENTIATION OF IMMU Page 1 [Frontiers in Bioscience 5 …

Protective immunity against malaria liver stage after vaccination with live parasites

L Renia - Parasite, 2008 - parasite-journal.org
Despite nearly 100 years of research and control efforts, malaria remains one of the most
important infectious diseases. An efficient vaccine would be a powerful to tool to reduce …

[HTML][HTML] Immunity to malaria: more questions than answers

J Langhorne, FM Ndungu, AM Sponaas, K Marsh - Nature immunology, 2008 - nature.com
Malaria is one of the main health problems facing developing countries today. At present,
preventative and treatment strategies are continuously hampered by the issues of the ever …

Malaria vaccine development: persistent challenges

AM Vaughan, SHI Kappe - Current opinion in immunology, 2012 - Elsevier
There is no licensed vaccine against any human parasitic disease and apicomplexan
parasites cause enormous human suffering; the malaria parasite alone kills approximately …

[HTML][HTML] Malaria vaccines: identifying Plasmodium falciparum liver-stage targets

RJ Longley, AVS Hill, AJ Spencer - Frontiers in microbiology, 2015 - frontiersin.org
The development of a highly efficacious and durable vaccine for malaria remains a top
priority for global health researchers. Despite the huge rise in recognition of malaria as a …