Vaccines that comprise attenuated viral vectors encoding antigens from target pathogens
generate potent T‐cell responses. One such pathogen is malaria, and in particular the liver …

Identification of correlates of protection for infectious diseases including malaria is a major
challenge and has become one of the main obstacles in developing effective vaccines. We …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

A heterologous prime‐boost strategy has been developed to potently induce T cell
responses to pre‐erythrocytic malaria antigens. Efficacy in the field is likely to depend on …

Introduction Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted
adaptive immunity to infection in peripheral organs. Harnessing TRM cells through …

Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Malaria vaccines aim to induce long lasting protective immunity. Bejon and colleagues
propose that levels of rapidly induced (effector memory) interleukin-2 and interferon gamma …

The observation that individuals living in malaria endemic areas fail to develop sterilizing
immunity to malaria infection has led to the assumption that malaria-specific immune …

T lymphocytes play a central role in the generation of a protective immune response in many
microbial infections. After immunization, dendritic cells take up microbial antigens and traffic …

Since malaria continues to account for millions of deaths annually in endemic regions, the
development of an effective vaccine remains highly desirable. The life cycle of malaria …