Autism and the synapse: emerging mechanisms and mechanism-based therapies

D Ebrahimi-Fakhari, M Sahin - Current opinion in neurology, 2015 - journals.lww.com
Identifying converging pathways in syndromic forms of ASD will uncover novel therapeutic
targets for non-syndromic ASD. Insights into developmental synaptopathies will lead to …

Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

H Won, W Mah, E Kim - Frontiers in molecular neuroscience, 2013 - frontiersin.org
Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by
impairments in social interaction and communication and restricted and repetitive …

Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders

W Spooren, L Lindemann, A Ghosh… - Trends in pharmacological …, 2012 - cell.com
Autism and autism spectrum disorders (ASDs) affect millions of individuals worldwide.
Despite increased autism diagnoses over the past 30 years, therapeutic intervention is often …

Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities

HY Zoghbi, MF Bear - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual
disabilities has greatly informed our understanding of the molecular pathways critical for …

Synaptopathology involved in autism spectrum disorder

S Guang, N Pang, X Deng, L Yang, F He… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

Autism spectrum disorders: multiple routes to, and multiple consequences of, abnormal synaptic function and connectivity

L Carroll, S Braeutigam, JM Dawes… - The …, 2021 - journals.sagepub.com
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders of genetic and environmental etiologies. Some ASD cases are syndromic …

[HTML][HTML] Postsynaptic autism spectrum disorder genes and synaptic dysfunction

P Bonsi, A De Jaco, L Fasano, P Gubellini - Neurobiology of disease, 2022 - Elsevier
This review provides an overview of the synaptic dysfunction of neuronal circuits and the
ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD) …

Genetic aspects of autism spectrum disorders: insights from animal models

S Banerjee, M Riordan, MA Bhat - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Autism spectrum disorders (ASDs) are a complex neurodevelopmental disorder that display
a triad of core behavioral deficits including restricted interests, often accompanied by …

Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity

J Gilbert, HY Man - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Current perspectives in autism spectrum disorder: from genes to therapy

M Chahrour, BJ O'Roak, E Santini… - Journal of …, 2016 - Soc Neuroscience
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental presentations with
high heritability and both phenotypic and genetic heterogeneity. To date, mutations in …