The challenges in successful vaccination against influenza using conventional approaches
lie in their variable efficacy in different age populations, the antigenic variability of the …

Mice recovered from influenza A virus infection have been shown to be cross-protected
against challenge infection with either drift viruses within a subtype (subtype-specific …

Several strategies are being pursued to increase the quality and quantity of influenza
vaccines that are used on an annual basis including increasing the immunogenicity of …

Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

Development of a universal influenza vaccine is a research priority for the National Institute
of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health. To facilitate …

Studying the spread of influenza in human populations and protection by influenza vaccines
provides important insights into immunity against influenza. The 2009 H1N1 pandemic has …

In preclinical studies, MF59 adjuvant offered improved protection against influenza virus
challenge and significantly reduced the viral load in the lungs of challenged mice. In …

Background The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against …

SEASONAL INFLUENZA VACCINES: Page 1 A SEASONAL INFLUENZA VACCINES: AN
OVERVIEW FOR DECISION-MAKERS SEASONAL INFLUENZA VACCINES: An overview for …

Influenza is controlled by protective titres of neutralizing antibodies, induced with the help of
CD4 T-cells, and by antiviral T-cell effector function. Adjuvants are essential for the efficient …