Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of …

Adjuvants are included in sub-unit or recombinant vaccines to enhance the potency of
poorly immunogenic antigens. Adjuvant discovery is as complex as it is a multidiscplinary …

Highlights•Vaccine reactogenicity can be misperceived as a greater risk than infectious
disease.•Public acceptance of side effects is reduced when infectious risks are perceived as …

Background No published meta-analyses have assessed efficacy and effectiveness of
licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to …

Background: Children have high morbidity and hospitalization rates from seasonal
influenza. Meta-analyses suggest that conventional inactivated influenza vaccines are of low …

The concept of stimulating the body's immune response is the basis underlying vaccination.
Vaccines act by initiating the innate immune response and activating antigen presenting …

Seasonal influenza continues to have a huge annual impact in the United States, accounting
for tens of millions of illnesses, hundreds of thousands of excess hospitalizations, and tens …

New generation vaccines will increasingly comprise highly purified recombinant proteins.
Unfortunately, these antigens are often poorly immunogenic. Therefore, adjuvants will be …

In the early 20th century, researchers experimented with diverse compounds such as alum
(aluminum salts), mineral oil, and killed mycobacteria to improve the immunogenicity of …

The majority of vaccine antigens currently under investigation represent recombinant
molecules or subunits of pathogens with little or no inherent immunostimulatory property …