[HTML][HTML] Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya
SH Hodgson, E Juma, A Salim, C Magiri, D Njenga… - Malaria journal, 2015 - Springer
Background Controlled human malaria infection (CHMI) studies, in which healthy volunteers
are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines …
are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines …
[HTML][HTML] Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites …
SH Hodgson, E Juma, A Salim, C Magiri… - Frontiers in …, 2014 - frontiersin.org
Background: Controlled human malaria infection (CHMI) studies are a vital tool to accelerate
vaccine and drug development. As CHMI trials are performed in a controlled environment …
vaccine and drug development. As CHMI trials are performed in a controlled environment …
[HTML][HTML] Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe
SH Sheehy, AJ Spencer, AD Douglas, BKL Sim… - PloS one, 2013 - journals.plos.org
Background Controlled human malaria infection (CHMI) studies have become a routine tool
to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have …
to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have …
[HTML][HTML] The Equatoguinean malaria vaccine initiative: from the launching of a clinical research platform to malaria elimination planning in Central West Africa
PF Billingsley, CD Maas, A Olotu… - The American journal …, 2020 - ncbi.nlm.nih.gov
Fifteen years of investment in malaria control on Bioko Island, Equatorial Guinea (EG),
dramatically reduced malaria-associated morbidity and mortality, but the impact has …
dramatically reduced malaria-associated morbidity and mortality, but the impact has …
[HTML][HTML] Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve …
GP Gómez-Pérez, A Legarda, J Muñoz, BKL Sim… - Malaria journal, 2015 - Springer
Background Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool
for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only …
for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only …
Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a …
Background WHO recently approved a partially effective vaccine that reduces clinical
malaria in children, but increased vaccine activity is required to pursue malaria elimination …
malaria in children, but increased vaccine activity is required to pursue malaria elimination …
[HTML][HTML] The controlled human malaria infection experience at the University of Maryland
DAJ Friedman-Klabanoff, MB Laurens… - The American journal …, 2019 - ncbi.nlm.nih.gov
Controlled human malaria infection (CHMI) is a powerful tool to evaluate the efficacy of
malaria vaccines and pharmacologics. Investigators at the University of Maryland, Baltimore …
malaria vaccines and pharmacologics. Investigators at the University of Maryland, Baltimore …
[HTML][HTML] Comparison of clinical and parasitological data from controlled human malaria infection trials
M Roestenberg, GA O'Hara, CJA Duncan, JE Epstein… - PLoS …, 2012 - journals.plos.org
Background Exposing healthy human volunteers to Plasmodium falciparum-infected
mosquitoes is an accepted tool to evaluate preliminary efficacy of malaria vaccines. To …
mosquitoes is an accepted tool to evaluate preliminary efficacy of malaria vaccines. To …
[HTML][HTML] Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and …
DI Stanisic, XQ Liu, SL De, MR Batzloff, T Forbes… - Malaria journal, 2015 - Springer
Background The ability to undertake controlled human malaria infection (CHMI) studies for
preliminary evaluation of malaria vaccine candidates and anti-malaria drug efficacy has …
preliminary evaluation of malaria vaccine candidates and anti-malaria drug efficacy has …
Controlled human malaria infection: applications, advances, and challenges
DI Stanisic, JS McCarthy, MF Good - Infection and immunity, 2018 - Am Soc Microbiol
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …