Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

Malaria is a major global health problem, with severe mortality in children living in sub-
Saharan Africa, and there is currently no licensed, effective vaccine. However, vaccine …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …

Immunization with irradiated sporozoites is currently the most effective vaccination strategy
against liver stages of malaria parasites, yet the mechanisms underpinning the success of …

Abstract Malaria results in> 1,000,000 deaths per year worldwide. Although no licensed
vaccine exists, much effort is currently focused on subunit vaccines that elicit CD8 T cell …

Tissue-resident memory CD8+ T (Trm) cells in the liver are critical for long-term protection
against pre-erythrocytic Plasmodium infection. Such protection can usually be induced with …

Despite decades of research, malaria remains a global health crisis. Current subunit vaccine
approaches do not provide efficient long-term, sterilizing immunity against Plasmodium …

Sterile protection against infection with Plasmodium sporozoites requires high numbers of
memory CD8 T cells. However, infections with unrelated pathogens, as may occur in areas …