Accelerated DNA methylation age: associations with PTSD and neural integrity
Background Accumulating evidence suggests that posttraumatic stress disorder (PTSD) may
accelerate cellular aging and lead to premature morbidity and neurocognitive decline …
accelerate cellular aging and lead to premature morbidity and neurocognitive decline …
Accelerated DNA methylation age: associations with posttraumatic stress disorder and mortality
Objective Recently developed indices of cellular age based on DNA methylation (DNAm)
data, referred to as DNAm age, are being used to study factors that influence the rate of …
data, referred to as DNAm age, are being used to study factors that influence the rate of …
Traumatic stress and accelerated DNA methylation age: a meta-analysis
Background Recent studies examining the association between posttraumatic stress
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
Epigenetic age acceleration and cognitive decline: a twin study
V Vaccarino, M Huang, Z Wang, Q Hui… - The Journals of …, 2021 - academic.oup.com
Background Little is known about the role of DNA methylation (DNAm) epigenetic age
acceleration in cognitive decline. Using a twin study design, we examined whether DNAm …
acceleration in cognitive decline. Using a twin study design, we examined whether DNAm …
[HTML][HTML] DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife
DNA methylation-based (DNAm) measures of biological aging associate with increased risk
of morbidity and mortality, but their links with cognitive decline are less established. This …
of morbidity and mortality, but their links with cognitive decline are less established. This …
Posttraumatic psychopathology and the pace of the epigenetic clock: a longitudinal investigation
BackgroundPosttraumatic stress disorder (PTSD) and stress/trauma exposure are cross-
sectionally associated with advanced DNA methylation age relative to chronological age …
sectionally associated with advanced DNA methylation age relative to chronological age …
[HTML][HTML] Accelerated DNA methylation aging and increased resilience in veterans: The biological cost for soldiering on
Accelerated epigenetic aging, the difference between the DNA methylation-predicted age
(DNAm age) and the chronological age, is associated with a myriad of diseases. This study …
(DNAm age) and the chronological age, is associated with a myriad of diseases. This study …
[HTML][HTML] Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans
KJ Bourassa, ME Garrett, A Caspi, M Dennis… - Translational …, 2024 - nature.com
People who experience trauma and develop posttraumatic stress disorder (PTSD) are at
increased risk for poor health. One mechanism that could explain this risk is accelerated …
increased risk for poor health. One mechanism that could explain this risk is accelerated …
A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD
DNA methylation patterns at specific cytosine-phosphate-guanine (CpG) sites predictably
change with age and can be used to derive “epigenetic age”, an indicator of biological age …
change with age and can be used to derive “epigenetic age”, an indicator of biological age …
DNA methylation age and physical and cognitive aging
J Maddock, J Castillo-Fernandez… - The Journals of …, 2020 - academic.oup.com
Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be
predictive of all-cause mortality but it is unclear what functional aspect (s) of aging it …
predictive of all-cause mortality but it is unclear what functional aspect (s) of aging it …