Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG
dinucleotides to accurately predict individual chronological age. A popular application of …

Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …

Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …

Aging is characterized by numerous molecular changes, such as accumulation of molecular
damage and altered gene expression, many of which are linked to DNA methylation. Here …

Replicative senescence has fundamental implications on cell morphology, proliferation, and
differentiation potential. Here, we describe a simple method to track long‐term culture based …

All mammals progress through similar physiological stages throughout life, from early
development to puberty, aging, and death. Yet, the extent to which this conserved …

A confounding aspect of biological ageing is the nature and role of senescent cells. It is
unclear whether the three major types of cellular senescence, namely replicative …

Epigenetic changes during ageing have been characterized by multiple epigenetic clocks
that allow the prediction of chronological age based on methylation status. Despite their …