Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Little is known about the regulation of neuronal and other cell-type specific epigenomes from
the brain. Here, we map the genome-wide distribution of trimethylated histone H3K4 …

Neural crest cells (NCC) are a transient, embryonic cell population characterized by unusual
migratory ability and developmental plasticity. To annotate and characterize cis-regulatory …

Understanding the complexity of the human brain and its functional diversity remain a major
challenge. Distinct anatomical regions are involved in an array of processes, including …

Mutations in gene regulatory elements have been associated with a wide range of complex
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …

Nuclear compartments are thought to play a role in three-dimensional genome organization
and gene expression. In mammalian brain, the architecture and dynamics of nuclear …

Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-
term chromatin remodeling around secondary response genes (SRGs). Here, we use high …

Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …

Despite the well established role of the frontal and posterior perisylvian cortices in many
facets of human-cognitive specializations, including language, little is known about the …

Neurodevelopmental disorders have a heritable component and are associated with region
specific alterations in brain anatomy. However, it is unclear how genetic risks for …