Characterizing autism spectrum disorders by key biochemical pathways

M Subramanian, CK Timmerman, JL Schwartz… - Frontiers in …, 2015 - frontiersin.org
The genetic and phenotypic heterogeneity of autism spectrum disorders (ASD) presents a
substantial challenge for diagnosis, classification, research, and treatment. Investigations …

Current perspectives in autism spectrum disorder: from genes to therapy

M Chahrour, BJ O'Roak, E Santini… - Journal of …, 2016 - Soc Neuroscience
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental presentations with
high heritability and both phenotypic and genetic heterogeneity. To date, mutations in …

Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity

J Gilbert, HY Man - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Autism spectrum disorder: signaling pathways and prospective therapeutic targets

J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …

The emerging picture of autism spectrum disorder: genetics and pathology

JA Chen, O Peñagarikano, TG Belgard… - Annual Review of …, 2015 - annualreviews.org
Autism spectrum disorder (ASD) is defined by impaired social interaction and
communication accompanied by stereotyped behaviors and restricted interests. Although …

Translational approaches to the biology of Autism: false dawn or a new era?

C Ecker, W Spooren, DGM Murphy - Molecular psychiatry, 2013 - nature.com
Discovering novel treatments for Autism Spectrum Disorders (ASD) is a challenge. Its
etiology and pathology remain largely unknown, the condition shows wide clinical diversity …

A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder

SS Purushotham, NMN Reddy, MN D'Souza… - Experimental Brain …, 2022 - Springer
Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2 …

[HTML][HTML] Novel mechanisms and treatment approaches in autism spectrum disorder

JA Brian, K Doyle-Thomas, D Baribeau… - Discovery …, 2016 - discoverymedicine.com
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized
by marked heterogeneity in biology, expression, and response to treatment. The past …

Functional neurogenomics in autism spectrum disorders: A decade of progress

LK Bicks, DH Geschwind - Current Opinion in Neurobiology, 2024 - Elsevier
Advances in autism spectrum disorder (ASD) genetics have identified many genetic causes,
reflecting remarkable progress while at the same time identifying challenges such as …

The neurobiology of autism

CA Pardo, CG Eberhart - Brain pathology, 2007 - Wiley Online Library
Improving clinical tests are allowing us to more precisely classify autism spectrum disorders
and diagnose them at earlier ages. This raises the possibility of earlier and potentially more …