Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration
of antigenic, co‐stimulatory and inflammatory signals undergo a programmed series of …

The immune system has adapted to effect different mechanisms to combat the multitude of
potential pathogens in our environment. In particular, CD8 T cells are participants in the …

CD8 T cells are an important part of the adaptive immune system providing protection
against intracellular bacteria, viruses, and protozoa. After infection and/or vaccination …

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …

Generating a large population of memory CD8 T cells is an appealing goal for vaccine
design against a variety of human diseases. Indeed, experimental models have …

Immunological memory provides rapid protection to pathogens previously encountered
through infection or vaccination. CD 4 T‐cells play a central role in all adaptive immune …

Immunological memory is one of the features that define the adaptive immune response: by
generating specific memory cells after infection or vaccination, the host provides itself with a …

Generating long-lasting, protective CD8+ T-cell memory via vaccination is critical for
combating infectious diseases. Advances in the past year have provided many new insights …

Memory CD8 T cells generated after acute viral infections or live vaccines can persist for
extended periods, in some instances for life, and play an important role in protective …