Plasmodium falciparum malaria is a major global health problem, responsible for up to 1
million deaths each year. Major efforts have been made to develop an effective vaccine …

Background Controlled human malaria infection (CHMI) studies have become a routine tool
to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have …

The development of an effective malaria vaccine has taken many decades, but there is now
a good chance that the first malaria vaccine will be licensed within the next few years …

In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …

Introduction: Malaria challenge models, where healthy human volunteers are intentionally
infected with Plasmodium species parasites under controlled conditions, can be undertaken …

There is increasing interest in malaria vaccines targeting the asexual blood stage of
Plasmodium falciparum. Without accepted immunologic correlates of clinical protection …

Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

Clinical trials are an essential step in evaluation of safety and efficacy of malaria vaccines,
and human experimental malaria infections have been used for evaluation of protective …

Malaria is a parasitic disease of major global health significance that causes an estimated
2.7 million deaths each year. In this review we describe the burden of malaria and discuss …

With over 1 million deaths annually attributed to malaria, an effective vaccine is an urgently
needed intervention. However, the various stages of the malaria parasite lifecycle have …