While recent progress has been made in reducing malaria mortality with other interventions,
vaccines are still urgently needed to further reduce the incidence of clinical disease …

Efforts to develop vaccines against malaria have been the focus of substantial research
activities for decades. Several categories of candidate vaccines are currently being …

Malaria is one of the most frequently occurring infectious diseases worldwide, with almost 1
million deaths and an estimated 243 million clinical cases annually. Several candidate …

Highlights•First malaria vaccine RTS, S induces anti-sporozoite antibodies to protect
children.•Whole-sporozoite vaccines induce T cells and antibodies and confer field …

New interventions are needed to reduce morbidity and mortality associated with malaria, as
well as to accelerate elimination and eventual eradication. Interventions that can break the …

From a total of 2.6 billion people at permanent risk of suffering malaria infection worldwide,
80-300 million experience Plasmodium vivax infections every year, with clinical …

BACKGROUND. Drugs and vaccines that can interrupt the transmission of Plasmodium
falciparum will be important for malaria control and elimination. However, models for early …

The quest for an efficacious malaria vaccine has been ongoing for nearly a century with
limited success. Malaria remains one of the most significant infectious diseases affecting …

Malaria remains a major global health challenge. Appropriate use of current antimalarial
tools has reduced the disease burden, but morbidity and mortality remain unacceptably …

Background Exposing healthy human volunteers to Plasmodium falciparum-infected
mosquitoes is an accepted tool to evaluate preliminary efficacy of malaria vaccines. To …