Over a century since Ronald Ross discovered that malaria is caused by the bite of an
infectious mosquito it is still unclear how the number of parasites injected influences disease …

The development and implementation of a malaria vaccine would constitute a major
breakthrough for global health. Recently, numerous new candidates have entered clinical …

Effective control and eventual eradication of malaria drives the imperative need for clinical
development of a malaria vaccine. Asexual parasite forms are responsible for clinical …

Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to
develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed …

Despite recent progress in reducing deaths attributable to malaria, it continues to claim
approximately 500,000 lives per year and is associated with approximately 200 million …

Malaria vaccine development has rapidly advanced in the past decade. The very first phase
3 clinical trial of the RTS, S vaccine was completed with over 15,000 African infants and …

Stimulated by recent advances in malaria control and increased funding, the elimination of
malaria is now considered to be an attainable goal for an increasing number of malaria …

Although Plasmodium falciparum is the leading cause of morbidity and mortality due to
malaria worldwide, nearly 2.5 billion people, mostly outside Africa, are also at risk from …

Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …

Publisher Summary This chapter discusses clinical malaria vaccines. Vaccination of the
individual as well as vaccination of communities within endemic areas is discussed, as is the …