Existing control measures have significantly reduced malaria morbidity and mortality in the
last two decades, although these reductions are now stalling. Significant efforts have been …

Highlights•Efficacy of RTS, S vaccine in children supports the concept of a malaria
vaccine.•RTS, S efficacy is limited and life-span is short so improvements are …

Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage
Plasmodium falciparum malaria parasite have so far shown disappointing results. The …

Mosquito stage, transmission blocking vaccines for malaria : Current Opinion in Infectious
Diseases Mosquito stage, transmission blocking vaccines for malaria : Current Opinion in …

A vaccine to reduce human suffering caused by malarial parasites has been the holy grail of
malaria research. Early studies in the 1940's indicated that attenuated parasites could …

Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite
have been widely used to assess efficacy of preerythrocytic vaccine candidates in small …

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …

The use of asexual blood-stage proteins as malaria vaccines is strongly supported by
experimental data directly implicating antibodies induced by these antigens in parasite …

Evidence accumulated through the years clearly indicates that antiparasite immune
responses can efficiently control malaria parasite infection at all development stages, and …

Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …