Vaccines are the most powerful public health tools mankind has created, but malaria
parasites are bigger, more complicated, and wilier than the viruses and bacteria that have …

Introduction: Despite recent advances, malaria remains a major health threat both to
populations in endemic areas as well travelers, including military personnel, to these areas …

The complex life cycle of the malaria parasite Plasmodium falciparum provides many
options for vaccine design. Several new types of vaccine are now being evaluated in clinical …

Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Abstract Development of bespoke biomanufacturing processes remains a critical bottleneck
for translational studies, in particular when modest quantities of a novel product are required …

The observation that inactivated Plasmodium sporozoites could protect against malaria is
about a hundred years old. However, systematic demonstration of protection using irradiated …

Despite identification of the etiologic agent a century ago and proof-ofprinciple nearly 50
years ago that acquired humoral immunity can prevent infection in mosquitoes feeding on a …

Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium
sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against …

Research on malaria vaccines is currently directed primarily towards the development of
vaccines that prevent clinical malaria. Malaria elimination, now being considered seriously …

Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but
parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent …