The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria

CV Plowe, P Alonso, SL Hoffman - The Journal of infectious …, 2009 - academic.oup.com
There has been a recent call for global malaria eradication. The prospects of achieving this
ambitious goal are diminished by the limited tool set now available—notably, the lack of a …

That was then but this is now: malaria research in the time of an eradication agenda

SHI Kappe, AM Vaughan, JA Boddey, AF Cowman - Science, 2010 - science.org
The global research community must take up the challenge to work toward the eradication of
malaria. In the past, malaria research has focused on drugs and vaccines that target the …

[HTML][HTML] Development of vaccines for Plasmodium vivax malaria

I Mueller, AR Shakri, CE Chitnis - Vaccine, 2015 - Elsevier
Plasmodium vivax continues to cause significant morbidity outside Africa with more than
50% of malaria cases in many parts of South and South-east Asia, Pacific islands, Central …

Uninfected mosquito bites confer protection against infection with malaria parasites

MJ Donovan, AS Messmore, DA Scrafford… - Infection and …, 2007 - Am Soc Microbiol
Despite decades of research and multiple initiatives, malaria continues to be one of the
world's most debilitating infectious diseases. New insights for malaria control and vaccine …

[HTML][HTML] Evaluation of the Pfs25-IMX313/Matrix-M malaria transmission-blocking candidate vaccine in endemic settings

C Mulamba, C Williams, K Kreppel, JB Ouedraogo… - Malaria Journal, 2022 - Springer
Malaria control relies heavily on the use of anti-malarial drugs and insecticides against
malaria parasites and mosquito vectors. Drug and insecticide resistance threatens the …

Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection

KE Lyke, AS Ishizuka, AA Berry… - Proceedings of the …, 2017 - National Acad Sciences
A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ
Vaccine), confers sterile protection against controlled human malaria infection (CHMI) with …

The path of malaria vaccine development: challenges and perspectives

C Arama, M Troye‐Blomberg - Journal of internal medicine, 2014 - Wiley Online Library
Malaria is a life‐threatening disease caused by parasites of the P lasmodium genus. In
many parts of the world, the parasites have developed resistance to a number of antimalarial …

[HTML][HTML] Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

FM Thompson, DW Porter, SL Okitsu, N Westerfeld… - PLoS …, 2008 - journals.plos.org
Background Previous research indicates that a combination vaccine targeting different
stages of the malaria life cycle is likely to provide the most effective malaria vaccine. This …

[HTML][HTML] Plasmodium vivax: who cares?

MR Galinski, JW Barnwell - Malaria journal, 2008 - Springer
More attention is being focused on malaria today than any time since the world's last efforts
to achieve eradication over 40 years ago. The global community is now discussing …

[HTML][HTML] Pre-erythrocytic vaccines against malaria

C Marques-da-Silva, K Peissig, SP Kurup - Vaccines, 2020 - mdpi.com
Malaria, caused by the protozoan Plasmodium, is a devastating disease with over 200
million new cases reported globally every year. Although immunization is arguably the best …