Parasitic protozoa cause considerable disease in humans and, due to their intracellular life
cycle, induce robust CD8+ T cell responses. A greater understanding of the factors that …

Immunization with irradiated sporozoites is currently the most effective vaccination strategy
against liver stages of malaria parasites, yet the mechanisms underpinning the success of …

While the role of malaria parasite-specific memory CD8+ T cells in the control of exo-
erythrocytic stages of malaria infection is well documented and generally accepted, a debate …

Highlights•Protective immunity against malaria can be achieved through immunisation with
live attenuated Plasmodium sporozoites and targets the parasite pre-erythrocytic …

Recently, a population of non-recirculating, tissue-resident memory CD8+ T cells has been
identified; cells that seems to act as key sentinels for invading microorganisms with …

Transgenic (Tg) mice carrying a T‐cell receptor (TCR) specific for a CD8+ T‐cell epitope
expressed in pre‐erythrocytic stages of Plasmodium yoelii has proven to be a valuable tool …

During the pre-erythrocytic asymptomatic phase of malarial infection, sporozoites develop
transiently inside less than 100 hepatocytes that subsequently release thousands of …

Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-
Class I antigen-processing pathway. After the introduction of Plasmodium sporozoites by …

Since the demonstration of sterile protection afforded by injection of irradiated sporozoites,
CD8+ T cells have been shown to play a significant role in protection from liver-stage …