IL-10–modulated human dendritic cells for clinical use: identification of a stable and migratory subset with improved tolerogenic activity

F Kryczanowsky, V Raker, E Graulich… - The Journal of …, 2016 - journals.aai.org
Dendritic cells (DCs) are key regulators of protective immune responses and tolerance to
(self-) Ags. Therefore, the scientific rationale for the use of tolerogenic DC therapy in the …

Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens

C Berberich, JR Ramírez-Pineda… - The Journal of …, 2003 - journals.aai.org
Upon loading with microbial Ag and adoptive transfer, dendritic cells (DC) are able to induce
immunity to infections. This offers encouragement for the development of DC-based …

Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma

E Henry, CJ Desmet, V Garzé, L Fiévez… - The Journal of …, 2008 - journals.aai.org
Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary
immune responses, including tolerogenic responses. We have genetically engineered bone …

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction—a comparative study of human clinical-applicable DC

MA Boks, JR Kager-Groenland, MSP Haasjes… - Clinical …, 2012 - Elsevier
Tolerogenic dendritic cells (tDC) are a promising tool for specific cellular therapy to induce
immunological tolerance in transplantation and autoimmunity. To date, most described tDC …

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity

SS Jensen, M Gad - Journal of inflammation, 2010 - Springer
Background Dendritic cells (DC) are main gate-keepers of the immune system, bridging the
innate and adaptive immune system. DCs are able to mature into inflammatory DCs at sites …

Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets

M Kuwana - Human immunology, 2002 - Elsevier
The induction of antigen-specific tolerance is critical for maintaining immune homeostasis
and preventing autoimmunity. Because the central tolerance that eliminates potentially …

The nature of activatory and tolerogenic dendritic cell-derived signal II

G Bakdash, SP Sittig, T Dijk, CG Figdor… - Frontiers in …, 2013 - frontiersin.org
Dendritic cells (DCs) are central in maintaining the intricate balance between immunity and
tolerance by orchestrating adaptive immune responses. Being the most potent antigen …

Interleukin 10 regulates cell surface and soluble LIR‐2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro

BG Beinhauer, JM McBride, P Graf… - European journal of …, 2004 - Wiley Online Library
Dendritic cells (DC) are unique in their ability to stimulate naive T cells to proliferate and to
differentiate into effector T cells. DC, however, can also inhibit T cell activation and play a …

Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis

N Novak, S Koch, JP Allam, T Bieber - Journal of Allergy and Clinical …, 2010 - Elsevier
Much knowledge has been gained about the multifaceted functions of dendritic cells (DCs).
The central role of various DC subtypes as bridges between innate and adaptive immunity …

Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)

M Comi, D Avancini, F Santoni de Sio, M Villa… - Cellular & Molecular …, 2020 - nature.com
Tolerogenic dendritic cells (DCs) are key players in maintaining immunological
homeostasis, dampening immune responses, and promoting tolerance. DC-10, a …