Recognition of microbial products through TLRs triggers the expression of several cytokines
that regulate innate and adaptive immunity. Signaling by various TLRs is not equivalent and …

LPS tolerance has been investigated extensively in monocytes/macrophages. However, the
LPS restimulation studies are not well documented in dendritic cells (DCs). In the present …

Epithelia represent a major portal of entry for pathogen microorganisms and allergens and
are equipped with innate and adaptive immunity for their protection. Pattern recognition …

Dendritic cells (DC) are key initiators of primary immune responses. Myeloid DC can secrete
IL-12, a potent Th1-driving factor, and are often viewed as Th1-promoting APC. Here we …

IL-10 is a critical cytokine that blocks the maturation of dendritic cells (DCs), but the
relevance of autocrine IL-10 on DC functions has not been investigated. In this study, we …

Summary Background High‐affinity IgE receptor (FcɛRI) expression on blood dendritic cells
reportedly correlates with serum IgE levels. Our studies demonstrate that plasmacytoid …

IL‐33, a new member of the IL‐1 family cytokine, is involved in Th2‐type responses in a
wide range of diseases and signals through the ST2 receptor expressed on many immune …

It has been postulated that low-level interleukin (IL)-12 production of antigen-presenting
cells is associated with the risk of developing atopic asthma. To study the relationship …

Th2 cell immunity is required for host defense against helminths, but it is detrimental in
allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by …

Allergy is an exacerbated response of the immune system against non-self-proteins called
allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE …