Prior studies have shown that subclasses of dendritic cells (DC) direct the development of
distinct Th populations in rodents and in humans. In the mouse, we have recently shown that …

BACKGROUND: Lactobacilli are probiotic bacteria that are frequently tested in the
management of allergic diseases or gastroenteritis. It is hypothesized that these probiotics …

Lack of sufficient IL-12 production has been suggested to be one of the basic underlying
mechanisms in atopy, but a potential role of IL-12 in established allergic airway disease …

Various populations of regulatory T (Treg) cells have been shown to play a central role in the
maintenance of peripheral homeostasis and the establishment of controlled immune …

Dendritic cells (DC) produce interleukin-12 (IL-12) in response to Toll-like receptor (TLR)
activation. Two major TLR signaling pathways participate in the response to pathogens: the …

Interleukin-10 (IL-10)–treated dendritic cells (DCs) induce an alloantigen-or peptide-specific
anergy in various CD4+ and CD8+ T-cell populations. In the present study, we analyzed …

Dendritic cells (DCs) discriminate different microbial pathogens and induce T-cell responses
of appropriate effector phenotypes accordingly. Microbial recognition and differentiation are …

Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell
origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as …

Background Optimization of the current dendritic cell (DC) culture protocol in order to
promote the therapeutic efficacy of DC-based immunotherapy is warranted. Alternative …

Allergic asthma is one of the most common chronic diseases in western society,
characterized by variable airway obstruction, mucus hypersecretion and infiltration of the …